Brain Health Research AMBAR (Alzheimer Management by Albumin Replacement) Study November 19, 2024 / June 13, 2025 by MCS The AMBAR (Alzheimer Management by Albumin Replacement) study explored a unique treatment approach that involves removing and replacing a portion of a person’s blood plasma—known as plasma exchange—to see if it might help slow the progression of Alzheimer’s disease. Researchers tested this procedure in people with mild-to-moderate Alzheimer’s, aiming to filter out and replace specific […] Read more
General Research Plasma exchange for Guillain-Barré syndrome November 6, 2024 / June 13, 2025 by MCS | Leave a Comment This systematic review examines the effectiveness of plasma exchange (PE) in treating Guillain-Barré syndrome, an acute inflammatory condition affecting peripheral nerves that often leads to paralysis. Guillain-Barré syndrome is believed to be caused by autoimmune responses, including harmful antibodies, which PE can help remove from the bloodstream. The procedure involves connecting the patient to a […] Read more Alzheimers Disease AMBAR AMBAR Study Apheresis biotech Grifols therapeutic plasma exchange tpe
Brain Health Research Neuroimaging analyses from a randomized, controlled study to evaluate plasma exchange with albumin replacement in mild‑to‑moderate Alzheimer’s disease: additional results from the AMBAR study November 6, 2024 / June 13, 2025 by MCS | Leave a Comment This study, part of the AMBAR phase 2b/3 clinical trial, investigated the effects of therapeutic plasma exchange (PE) with albumin replacement on brain structure and function in patients with mild-to-moderate Alzheimer’s disease (AD). Patients were divided into four groups: three received PE with varying doses of albumin (some with intravenous immunoglobulin, IVIG), while the fourth […] Read more Alzheimers Disease AMBAR AMBAR Study Apheresis biotech Grifols therapeutic plasma exchange tpe
Brain Health Research Rejuvenation of three germ layers tissues by exchanging old blood plasma with saline-albumin November 6, 2024 / June 13, 2025 by MCS | Leave a Comment This phase 2b/3 trial evaluated the effects of plasma exchange (PE) with albumin replacement on patients with mild-to-moderate Alzheimer’s disease (AD). A total of 347 patients were randomized into three This study challenges the idea that young blood is necessary for tissue rejuvenation, showing instead that “neutral blood exchange” (NBE) — replacing half of an […] Read more Alzheimers Disease AMBAR AMBAR Study Apheresis biotech Grifols therapeutic plasma exchange tpe
Brain Health Research A randomized, controlled clinical trial of plasma exchange with albumin replacement for Alzheimer’s disease: Primary results of the AMBAR Study November 6, 2024 / June 13, 2025 by MCS | Leave a Comment This phase 2b/3 trial evaluated the effects of plasma exchange (PE) with albumin replacement on patients with mild-to-moderate Alzheimer’s disease (AD). A total of 347 patients were randomized into three treatment groups with varying doses of albumin and intravenous immunoglobulin (IVIG) or a placebo group. The treatment included an initial 6-week period of weekly PE, […] Read more Alzheimers Disease AMBAR AMBAR Study Apheresis biotech Grifols therapeutic plasma exchange tpe
Brain Health Research Efficacy and Safety of Plasma Exchange with 5% Albumin to Modify Cerebrospinal Fluid and Plasma Amyloid-β Concentrations and Cognition Outcomes in Alzheimer’s Disease Patients: A Multicenter, Randomized, Controlled Clinical Trial November 6, 2024 / June 13, 2025 by MCS | Leave a Comment This study examined whether plasma exchange (PE) with albumin replacement could alter amyloid-β (Aβ) levels in cerebrospinal fluid (CSF) and plasma and improve cognitive function in patients with mild-to-moderate Alzheimer’s disease (AD). In this phase II trial, 42 AD patients were assigned to either PE treatment or a control group. Treated patients received up to […] Read more Alzheimers Disease AMBAR AMBAR Study Apheresis biotech Grifols therapeutic plasma exchange tpe
Aging Research Application of biological age assessment of Chinese population in potential anti-ageing technology November 6, 2024 / June 13, 2025 by MCS | Leave a Comment This study aimed to create a biological age assessment formula for the Chinese population and evaluate the effectiveness of double filtration plasmapheresis as an anti-aging intervention. Researchers recruited 915 participants, analyzing 34 blood markers to identify aging biomarkers and develop a biological age formula for both males and females. Double filtration plasmapheresis was then tested […] Read more Alzheimers Disease AMBAR AMBAR Study Apheresis biotech Grifols therapeutic plasma exchange tpe
Aging Research Diluting blood plasma rejuvenates tissue, reverses aging in mice November 6, 2024 / June 13, 2025 by MCS | Leave a Comment UC Berkeley researchers found that diluting the blood plasma of old mice with a saline and albumin solution—without using young blood—rejuvenates tissues in the brain, liver, and muscles. This “neutral blood exchange” lowers harmful, age-associated proteins and allows beneficial proteins to rebound, providing effects similar to or better than young blood transfusions. Key findings include: […] Read more Alzheimers Disease AMBAR AMBAR Study Apheresis biotech Grifols therapeutic plasma exchange tpe
Aging Research Attenuation of age-elevated blood factors by repositioning plasmapheresis: A novel perspective and approach November 6, 2024 / June 13, 2025 by MCS | Leave a Comment This review discusses how aging impairs stem cell activation, leading to tissue decline and an increased risk of age-related diseases. Aging tissues release factors into the bloodstream that can disrupt the function of distant tissues, contributing to degenerative conditions and serving as biomarkers for age-related diseases. The review highlights recent research on reducing these harmful […] Read more Alzheimers Disease AMBAR AMBAR Study Apheresis biotech Grifols therapeutic plasma exchange tpe
Brain Health Research Plasma dilution improves cognition and attenuates neuroinflammation in old mice November 6, 2024 / June 13, 2025 by MCS | Leave a Comment This study reveals that “neutral blood exchange” (NBE)—a procedure that dilutes old blood plasma without adding young blood factors—can rejuvenate tissues and improve brain function in aged mice. Unlike young blood infusions, NBE resets the body’s signaling environment, enhancing muscle and liver repair, hippocampal neurogenesis, and cognitive performance in older mice. Key findings include: These […] Read more Alzheimers Disease AMBAR AMBAR Study Apheresis biotech Grifols therapeutic plasma exchange tpe
Aging Research Study shows that diluting blood plasma ‘resets’ aging November 6, 2024 / June 13, 2025 by MCS | Leave a Comment A study by researchers at UC Berkeley demonstrated that diluting old blood plasma with saline and albumin rejuvenates organs in mice without the need for young blood. This method, which replaces half of the old plasma, improved the health and function of organs like the brain, liver, and muscles by lowering pro-inflammatory proteins associated with […] Read more Alzheimers Disease AMBAR AMBAR Study Apheresis biotech Grifols therapeutic plasma exchange tpe
Aging Research The hope of rejuvenation: using plasma to reverse ageing in mice November 6, 2024 / June 13, 2025 by MCS | Leave a Comment A study by UC Berkeley researchers shows that diluting old mice’s blood plasma with a mixture of saline and albumin (without using young blood) can rejuvenate tissues in organs like the brain, liver, and muscles. This approach, which replaces half of the old plasma with basic components, produced similar or better results than pairing with […] Read more Alzheimers Disease AMBAR AMBAR Study Apheresis biotech Grifols therapeutic plasma exchange tpe
