The Science of Feeling Better, Longer
Longevity medicine, built for you.
Concierge therapeutic plasma exchange.
Your biology is unique. Your protocol should be too.
I just wanted to say THANK YOU for all you have done for me. I cannot express how much it has meant to me. Once my body adjusted to the plasmapheresis it has been like a miracle to me!Karen – Lifespan Edge Client | Age 62 · Patient since 2026
Actual plasma removed during a single TPE session. This is what decades of inflammatory proteins and pro-aging factors look like.
The Foundation
Therapeutic Plasma Exchange: A total-body renewal at the cellular level.
Therapeutic Plasma Exchange filters your blood, removing inflammatory proteins, damaged molecules, and pro-aging factors that accumulate over time — then replaces them with clean fluid. Think of it as an oil change for your body.
It’s not experimental. TPE has been FDA-recognized for over 111 clinical indications and used in hospitals for decades. It’s the foundation of every Lifespan Edge protocol — the starting point your physician builds around.
Physician-led. Data-driven. Tailored to you.
Every Lifespan Edge protocol follows the same physician-led standard, designed by our co-founder, Dr. Michael Roizen, four-time #1 New York Times bestseller. Here’s how our plasma exchange works.
Consultation & Biomarker Panel
We pull comprehensive labs before your first session. Your physician reviews them with you to learn about your baseline and your goals.
TPE Protocol Design
Your unique therapeutic plasma exchange protocol is developed from Dr. Roizen’s targeted framework, your bloodwork, and your goals. Nothing about it is off the shelf.
Treatment & Measurement
We run biomarkers based on your specific protocols.
Ongoing Refinement
We don’t set it and forget it. Your protocol evolves with every cycle, tailored to your labs and personal results.
Don’t take our word for it. Take theirs .
Richard
TPE Patient · Dallas Clinic
Song
TPE Patient · Dallas Clinic
“To feel like this versus what I did two years ago, TPE is one of the main things I am continuing!”Richard · TPE Patient, Dallas Clinic
“One of the best things I’ve ever done for my health.”Song · TPE Patient, Dallas Clinic
Watch the Documentary
See why physicians are calling TPE the most promising longevity treatment available today.
Meet the founders, the science, and the patients who are rewriting the rules of aging.
Built around your goals, not a template.
Your protocol is shaped by your biomarkers, your goals, and your physician. Clients pursue TPE and longevity medicine for a wide range of goals and concerns — here are some of the most common.
Meet the team behind the Lifespan Edge.
Architect of the Lifespan Edge clinical standard. Four #1 NYT bestsellers. 188+ peer-reviewed publications shaping modern longevity medicine.
188+ Publications · 4 #1 NYT Bestsellers Meet Dr. Roizen →
Decades at the intersection of economics and foresight. A voice trusted by investors, institutions, and longevity-minded readers worldwide.
1M+ Weekly Readers · 20+ Years Meet John Mauldin →Find Us
Multiple clinics. One cutting-edge protocol.
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Dallas, Texas
Minutes from The Star in Frisco
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West Palm Beach, Florida
Minutes from downtown West Palm Beach.
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Columbia, Maryland
Minutes from downtown Columbia.
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Dorado Beach, Puerto Rico
Minutes from Dorado Beach.
The Research
Backed by leading science, guided by experience.
Over 1,400 peer-reviewed studies on plasma exchange and longevity demonstrate that what’s circulating in your blood directly affects how you age. Read the research yourself — then talk to our team.
Evidence Hub
Featured Research
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Therapeutic Plasma Exchange
Therapeutic Plasma Exchange as a Tool for Reversing Age-Related System Dysfunction With A Special Emphasis…
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An Introduction to Therapeutic Plasma Exchange
Therapeutic Plasma Exchange (TPE): Advancing Health and Longevity By Dr. Allen Green Introduction Imagine a…
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How does Therapeutic Plasma Exchange (TPE) make you and your body and mind younger?
By Dr. Mike Roizen As we stand on the cusp of revolutionary advances in medical…
Ready to see what’s Possible?
Our clinical team will walk you through your goals, your biomarkers, and whether the Lifespan Edge approach is right for you.