About Lifespan Edge
Shaping the future of longevity and wellness.
Lifespan Edge is a longevity clinic at the frontier of science, offering personalized, data-driven treatments like Therapeutic Plasma Exchange (TPE) to help people live longer, healthier, and more vibrant lives.
Our approach
A more proactive model of longevity care.
Our approach combines advanced testing, physician-led care, and personalized longevity protocols shaped by Dr. Michael Roizen, one of the country’s leading voices in preventive medicine.
Where care begins today
Today, that care begins with therapeutic plasma exchange, or TPE, a treatment designed to remove and replace a portion of a patient’s plasma as part of a broader longevity protocol.
What’s included
Advanced diagnostic testing
Physician-led, personalized care
Protocols built around your goals
What sets us apart
A different standard for longevity care.
Five principles guide the Lifespan Edge approach, in combination with Dr. Michael Roizen’s longevity framework.
Science-Led
Evidence-based treatments backed by world-class researchers and clinicians.
Personalized
Every protocol is tailored based on biomarker data and individual goals.
Innovative
We stay at the edge of biotechnology to push what’s possible.
Luxury Experience
Concierge care meets cutting-edge science in every visit.
Data-Driven
Your treatment is guided by numbers, not guesswork.
The co-founders
Meet the people behind Lifespan Edge.
Lifespan Edge was founded by John Mauldin and Dr. Michael Roizen, longtime friends with a shared passion for innovation and longevity medicine.
John Mauldin
Co-Founder
John Mauldin is a respected financial writer, investor, and publisher known for helping readers think clearly about the future, risk, and preparation. His personal experience with family history, cognitive health, and proactive longevity care helped shape the founding vision for Lifespan Edge.
Founder conversation
Why John and Mike built Lifespan Edge.
In this conversation, John Mauldin and Dr. Michael Roizen discuss the personal story behind Lifespan Edge, the science that shaped their approach, and why they believe longevity care should begin before decline becomes obvious.
John Mauldin · Co-Founder
Our story
For John Mauldin, this was personal.
For John, the idea behind Lifespan Edge came from lived experience and the drive to make a difference for families like his.
After watching his father and several family members experience dementia and memory loss, John began noticing early cognitive changes in himself. He wanted to understand what was happening, what options were available, and what he could do while there was still time to act.
He did not want to wait and wonder.
That search led him to therapeutic plasma exchange, also known as plasmapheresis, and to a deeper conversation with his longtime friend, Dr. Michael Roizen, about the future of longevity medicine.
In 2024, the two joined forces to build a new kind of clinic, one that pairs rigorous, evidence-based science with deeply personal care. What began as one man’s search became the foundation for Lifespan Edge: a longevity clinic built for patients who want to take aging seriously, before decline becomes obvious.
Locations
Available Nationwide.
Lifespan Edge brings the same clinical philosophy to every location: physician-led care, personalized protocols, and a shared standard for proactive longevity medicine.
-
Dallas, Texas
Minutes from The Star in Frisco
-
West Palm Beach, Florida
Minutes from downtown West Palm Beach.
-
Columbia, Maryland
Minutes from downtown Columbia.
-
Dorado Beach, Puerto Rico
Minutes from Dorado Beach.
Research
The research that shaped our thinking.
Therapeutic plasma exchange is being studied in many areas related to aging, inflammation, and cognitive health. While longevity applications are still emerging, the research has helped shape how Lifespan Edge thinks about proactive care.
-
How Plasma Exchange Could Help Turn Back the Clock on Aging
A recent study explored how a procedure called therapeutic plasma exchange (TPE) could slow down the biological aging process. TPE involves removing a person’s blood plasma and replacing it with a plasma substitute, sometimes combined with immunoglobulins (IVIG). The study showed that this procedure not only helps “reset” the body’s internal systems…
-
AMBAR (Alzheimer Management by Albumin Replacement) Study
The AMBAR (Alzheimer Management by Albumin Replacement) study explored a unique treatment approach that involves removing and replacing a portion of a person’s blood plasma—known as plasma exchange—to see if it might help slow the progression of Alzheimer’s disease. Researchers tested this procedure in people with mild-to-moderate Alzheimer’s, aiming to filter out…
-
Therapeutic Plasma Exchange
Therapeutic Plasma Exchange as a Tool for Reversing Age-Related System Dysfunction With A Special Emphasis On Reversing Brain Dysfunction By Patrick Cox, Research Analyst, Lifespan Edge, Inc. Brief Foreword By Dr. Michael Roizen & John Mauldin, Co-Founders, Lifespan Edge, Inc. This brief paper by Patrick Cox does the important job…
-
An Introduction to Therapeutic Plasma Exchange
Therapeutic Plasma Exchange (TPE): Advancing Health and Longevity By Dr. Allen Green Introduction Imagine a therapy that not only treats serious conditions but may also slow the aging process—this is the promise of therapeutic plasma exchange (TPE). TPE is a cutting-edge medical procedure that holds the potential to revolutionize health and longevity.…
Research into TPE for longevity and cognitive health is emerging. Nothing here implies that therapeutic plasma exchange prevents Alzheimer’s, reverses aging, or guarantees outcomes.
In the Press.
Lifespan Edge and Dr. Michael Roizen have been featured in conversations about longevity science, therapeutic plasma exchange, and the future of proactive care.
The New Science of Longevity with Dr. Michael Roizen
Dr. Michael Roizen discusses the science behind living longer, healthier lives, including emerging research in plasma therapy, cognitive health, aging, sleep, exercise, stress, and daily longevity practices.
Lifespan Edge opens Dorado clinic as part of regional expansion
Coverage of Lifespan Edge’s Dorado Beach clinic opening, highlighting growing demand for physician-guided longevity care and therapeutic plasma exchange.
If You Own the First Hour of Your Day, You Own Everything That Follows
An article featuring Dr. Roizen’s approach to longevity as a set of consistent daily practices, reinforcing the idea that healthspan is built through repeated, thoughtful action.
Ready to take the next step?
Speak with the Lifespan Edge team to learn whether therapeutic plasma exchange may be appropriate for your health goals.