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Research

Therapeutic Plasma Exchange

/ by John mauldin III

Therapeutic Plasma Exchange as a Tool for Reversing Age-Related System Dysfunction With A Special Emphasis On Reversing Brain Dysfunction By Patrick Cox, Research Analyst, Lifespan Edge, Inc.   Brief Foreword  By Dr. Michael Roizen & John Mauldin, Co-Founders, Lifespan Edge, Inc.   This brief paper by Patrick Cox does the important job of summarizing thousands […]

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General Research

Plasma exchange for Guillain-Barré syndrome

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This systematic review examines the effectiveness of plasma exchange (PE) in treating Guillain-Barré syndrome, an acute inflammatory condition affecting peripheral nerves that often leads to paralysis. Guillain-Barré syndrome is believed to be caused by autoimmune responses, including harmful antibodies, which PE can help remove from the bloodstream. The procedure involves connecting the patient to a […]

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Brain Health Research

Neuroimaging analyses from a randomized, controlled study to evaluate plasma exchange with albumin replacement in mild‑to‑moderate Alzheimer’s disease: additional results from the AMBAR study

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This study, part of the AMBAR phase 2b/3 clinical trial, investigated the effects of therapeutic plasma exchange (PE) with albumin replacement on brain structure and function in patients with mild-to-moderate Alzheimer’s disease (AD). Patients were divided into four groups: three received PE with varying doses of albumin (some with intravenous immunoglobulin, IVIG), while the fourth […]

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Brain Health Research

Rejuvenation of three germ layers tissues by exchanging old blood plasma with saline-albumin

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This phase 2b/3 trial evaluated the effects of plasma exchange (PE) with albumin replacement on patients with mild-to-moderate Alzheimer’s disease (AD). A total of 347 patients were randomized into three This study challenges the idea that young blood is necessary for tissue rejuvenation, showing instead that “neutral blood exchange” (NBE) — replacing half of an […]

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Brain Health Research

A randomized, controlled clinical trial of plasma exchange with albumin replacement for Alzheimer’s disease: Primary results of the AMBAR Study

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This phase 2b/3 trial evaluated the effects of plasma exchange (PE) with albumin replacement on patients with mild-to-moderate Alzheimer’s disease (AD). A total of 347 patients were randomized into three treatment groups with varying doses of albumin and intravenous immunoglobulin (IVIG) or a placebo group. The treatment included an initial 6-week period of weekly PE, […]

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Brain Health Research

Efficacy and Safety of Plasma Exchange with 5% Albumin to Modify Cerebrospinal Fluid and Plasma Amyloid-β Concentrations and Cognition Outcomes in Alzheimer’s Disease Patients: A Multicenter, Randomized, Controlled Clinical Trial

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This study examined whether plasma exchange (PE) with albumin replacement could alter amyloid-β (Aβ) levels in cerebrospinal fluid (CSF) and plasma and improve cognitive function in patients with mild-to-moderate Alzheimer’s disease (AD). In this phase II trial, 42 AD patients were assigned to either PE treatment or a control group. Treated patients received up to […]

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Aging Research

Application of biological age assessment of Chinese population in potential anti-ageing technology

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This study aimed to create a biological age assessment formula for the Chinese population and evaluate the effectiveness of double filtration plasmapheresis as an anti-aging intervention. Researchers recruited 915 participants, analyzing 34 blood markers to identify aging biomarkers and develop a biological age formula for both males and females. Double filtration plasmapheresis was then tested […]

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Aging Research

Diluting blood plasma rejuvenates tissue, reverses aging in mice

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UC Berkeley researchers found that diluting the blood plasma of old mice with a saline and albumin solution—without using young blood—rejuvenates tissues in the brain, liver, and muscles. This “neutral blood exchange” lowers harmful, age-associated proteins and allows beneficial proteins to rebound, providing effects similar to or better than young blood transfusions. Key findings include: […]

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Aging Research

Attenuation of age-elevated blood factors by repositioning plasmapheresis: A novel perspective and approach

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This review discusses how aging impairs stem cell activation, leading to tissue decline and an increased risk of age-related diseases. Aging tissues release factors into the bloodstream that can disrupt the function of distant tissues, contributing to degenerative conditions and serving as biomarkers for age-related diseases. The review highlights recent research on reducing these harmful […]

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Brain Health Research

Plasma dilution improves cognition and attenuates neuroinflammation in old mice

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This study reveals that “neutral blood exchange” (NBE)—a procedure that dilutes old blood plasma without adding young blood factors—can rejuvenate tissues and improve brain function in aged mice. Unlike young blood infusions, NBE resets the body’s signaling environment, enhancing muscle and liver repair, hippocampal neurogenesis, and cognitive performance in older mice. Key findings include: These […]

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Aging Research

Study shows that diluting blood plasma ‘resets’ aging

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A study by researchers at UC Berkeley demonstrated that diluting old blood plasma with saline and albumin rejuvenates organs in mice without the need for young blood. This method, which replaces half of the old plasma, improved the health and function of organs like the brain, liver, and muscles by lowering pro-inflammatory proteins associated with […]

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Aging Research

The hope of rejuvenation: using plasma to reverse ageing in mice

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A study by UC Berkeley researchers shows that diluting old mice’s blood plasma with a mixture of saline and albumin (without using young blood) can rejuvenate tissues in organs like the brain, liver, and muscles. This approach, which replaces half of the old plasma with basic components, produced similar or better results than pairing with […]

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