Frequently Asked Questions
Clear answers, grounded in science.
Learn how Therapeutic Plasma Exchange works, what the research shows, and what to expect as you consider whether a consultation is right for you.
The Treatment
What is Therapeutic Plasma Exchange (TPE), and how can it help me?
TPE is a clinical treatment that removes inflammatory proteins and toxins from your blood, replacing the plasma with a clean, sterile solution. It’s designed to support longevity, cognition, immune balance, and energy, offering what we call a “cellular reset.”
Who is a good fit for Lifespan Edge’s treatments?
Our clients include people who want to slow aging, improve memory and focus, boost performance, manage chronic inflammation, or recover from long-term conditions. Whether you’re a high-achieving professional or simply focused on staying healthy for the long run, we can tailor TPE to your goals.
How do you personalize my treatment?
We design your protocol around your biomarker data and your goals. Your plan evolves with you, using ongoing measurements and the latest research to stay truly personalized.
Science & Safety
Is Therapeutic Plasma Exchange (TPE) safe and backed by research?
Yes. TPE has a long track record of safety in both standard and emerging applications. Research, including the AMBAR trial for Alzheimer’s, has explored its potential in slowing disease progression and supporting cognitive health. TPE is well-studied and widely used in clinical settings, and ongoing research continues to explore its benefits for longevity and brain health.
Is Therapeutic Plasma Exchange (TPE) FDA-approved?
The FDA approves the devices used to perform TPE and allows physicians to decide which diseases or ailments would benefit from the procedure.
Is there research behind this treatment?
Absolutely. We curate the research so your care reflects the most up-to-date science. You can explore the studies we follow for yourself.
Your Experience
What happens during a therapeutic plasma exchange session?
Each session lasts about three hours in a private, calming clinic setting. We use two small IVs, with no sedation needed. You can relax, read, or stream something while your blood is gently refreshed.
When will I feel results?
Many people notice clearer thinking, more energy, and less inflammation within days of their first session. The benefits build over time as your personalized plan unfolds.
Getting Started
Will I be treated by Dr. Roizen?
As our Co-Founder, Dr. Roizen shapes everything we do. All Lifespan Edge protocols are designed around his longevity framework. While he can’t personally see every patient, he is heavily involved in designing our treatment protocols and guiding our clinical team, so his expertise informs your care from day one.
What happens during the free consultation?
Our team will review your health goals and biomarker data, and help you decide whether TPE is a good fit. You’ll leave with a clear, personalized plan. No pressure, just helpful guidance. Learn more about our services and process.
Why don’t you accept health insurance?
Staying independent from insurance lets us offer the latest, most advanced longevity treatments without delays or restrictions. That means faster, more customized care that keeps pace with the science.
Where are your clinics?
Please see a full list of our locations.
Go Deeper
A closer look at TPE.
Explore the research behind TPE, how the process works, and where to begin if you’re considering treatment.
Read the AMBAR Study
Explore the clinical study that examined plasma exchange as part of a therapeutic approach for Alzheimer’s disease.
How TPE Works
A step-by-step look at the procedure, from consultation to follow-up labs.
Find a Clinic
Explore current Lifespan Edge locations and learn where new clinics are opening next.
Still have questions? Let’s talk.
The fastest way to get answers specific to you is a free, no-pressure conversation with our clinical team. We’ll review your goals and help you decide if TPE is right for you.